No problem at all. I guess I have lots of cushioning on my rear end because I felt a slight pin prick and nothing else. It is a big needle but I was careful not to look at it.
The doctor and nurse said not to expect any side effects at all except for slight soreness at the spot of injection. I have had a few crampy twinges at that spot, but nothing else.
Edited to add:
I will get them once a week, from weeks 16 to 36.
Basilbean wrote that she knows of some women who have to do these shots at home, I’d suggest your partner do it, with you standing up and leaning over a table. Our nurse said that’s the least painful way and I honestly didn’t feel much at all.